First-of-its-Kind Randomized Clinical Trial Published in
The Lancet Infectious Diseases Outlines Potential New
Standard-Setting Best Practices for Peripheral IV Catheters (PIVCs)

There is robust evidence that the BD vascular care solution and skin antiseptics for peripheral IV catheters used in the CLEAN3 Randomized Clinical Trial can help improve patient outcomes.

Compared with standard approaches, the BD vascular care solution reduced the relative risk of catheter failure by 27%, resulting in longer catheter dwell time without complications.

The use of 2% chlorhexidine (CHG) 70% isopropyl alcohol (IPA) single use, sterile pre-filled applicator skin antiseptic reduced the risk of infectious complications (catheter colonization and local infection) by 92% compared with 5% povidone iodine (PVI) 69% ethanol.

Using a vascular care solution can help improve outcomes for patients requiring peripheral intravenous catheters (PIVCs).





The results of the CLEAN31 trial, published in the February edition of The Lancet Infectious Diseases, showed the use of a BD vascular care solution resulted in fewer PIVC failures compared with the standard group (34.8% vs. 47.5%. respectively) and extended the median time between catheter insertion and failure (50.4 hours vs 30.0 hours, respectively).

The CLEAN3 trial also evaluated skin antiseptics with 2% chlorhexidine-gluconate (CHG) 70% isopropyl alcohol (IPA) single use, sterile applicator, versus 5% povidone iodine (PVI) 69% ethanol, in preventing infectious complications related to the use of PIVCs (Catheter colonization: 0.9% vs. 16.9%, respectively; Local infection: 0% vs. 1.2%, respectively).

The trial, which involved approximately 1,000 patients from nine different medical wards within a single university hospital (Poitiers University Hospital, France), evaluated PIVC failure rates by comparing the BD vascular care solution for peripheral IV catheters, which included an integrated PIVC (BD Nexiva™), a positive displacement needle-free connector (BD MaxZero™), a disinfecting cap (BD PureHub™) and a sterile prefilled flush syringe (BD Posiflush™) — compared with a standard group — which included a straight safety PIVC (BD Insyte™ Autoguard™ BC Winged) and an extension set three-way stopcock.



PIVCs are the most commonly used invasive medical devices in hospitals, where about 2 billion are placed annually worldwide2,3.

However, in hospitals, 35% to 50% of PIVCs do not meet their intended dwell time and need to be removed prematurely due to preventable complications, such as infection, occlusion, phlebitis, dislodgement and infiltration/extravasation2.

 

This can lead to longer hospital stays, higher inpatient costs, and great risk of death than patients without these preventable complications4.

 

In addition, unnecessary PIVC replacement can be painful to patients and lead to additional costs5, as well as have an effect on health care professionals’ ability to support other patients.

 

Bloodstream infections can have an even greater impact, by prolonging hospitalization and increasing treatment costs and mortality4.

Chloraprep™ is een geneesmiddel dat uitsluitend bij de apotheker of drogist kan verkregen worden.

ChloraPrep™ 2% w/v / 70% v/v, oplossing voor cutaan gebruik Chloraprep™ bevat een snelwerkende antiseptische oplossing, waarmee de huid wordt gedesinfecteerd en infecties worden voorkomen voorafgaand aan invasieve medische ingrepen, zoals injecties, het inbrengen van katheters en lichte en zware operaties.
U mag dit medicijn niet gebruiken wanneer u allergisch (overgevoelig) bent voor chloorhexidinegluconaat of één van de stoffen in dit medicijn, vooral als u in het verleden mogelijk allergische reacties hebt gehad die zijn veroorzaakt door chloorhexidine.
Naast chloorhexidinegluconaat bevat dit geneesmiddel isopropylalcohol en gezuiverd water. Lees aandachtig de bijsluiter. Dit is publieksreclame bestemd voor de doelgroep die omwille van beroepsredenen baat heeft bij informatie/reclame over infectiepreventie, bijvoorbeeld artsen, verpleegkundigen, infectie preventie specialisten en kwaliteitsmanagers.

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