Determining risk of intubation with mechanical ventilation and mortality in COVID-19 patients
Validation of T-cell cutoff values in hospitalized COVID-19 patients – comparison with other commonly used laboratory parameters
Learn more about the retrospective validation of T-cell cutoffs values for CD4+ and CD8+ lymphocyte subsets in an Italian cohort of 160 COVID-19 patients.
Commonly used laboratory tests such as total lymphocytes, neutrophil-to-lymphocyte ratio, CRP, D-dimer and ferritin were compared in their predictive value to CD4+ and CD8+ T-cell cutoffs. In an exploratory analyses, CD4⁺ and CD8⁺ T-cell cutoffs were used together with an IL-6 cutoff.
Feel more secure when managing COVID-19 patient risk
Upon admission to hospitals, a major challenge for clinicians is to identify COVID-19 patients with an increased risk of intubation with mechanical ventilation (IMV) and an increased risk of mortality.
Early recognition of increased risk may inform the right course of action for patients while prioritizing precious resources.
Assess COVID-19 patient risk at hospitalization
T-cell subset counts at hospitalization can aid in determining the risk of intubation with mechanical ventilation (IMV) and risk of mortality, in conjunction with clinical findings and the results of other laboratory procedures.
Relative risks are ~5–6x higher for IMV and 4.5x higher for mortality for patients with T-cell subset counts below cut-off levels.
Cut-off values for specific lymphocyte T-cells subsets (CD4+ and/ or CD8+) to identify COVID-19 patients at risk
T-cell subsets typically decrease with increasing disease severity in COVID-19 patients.1
Based on available clinical data, PCR-confirmed COVID-19 patients who have a CD4+ T-cell count <250 cells/μL or CD8+ T-cell count <100 cells/μL, or both CD4+ and CD8+ T-cell counts below their respective cutoffs, are at increased risk for intubation with mechanical ventilation, and increased risk of mortality, during hospitalization.
CD4+ and CD8+ T-cell counts should be used in conjunction with clinical findings and the results of other laboratory testing. CD4+ and/or CD8+ T-cell counts alone are not indicative of the need for intubation with mechanical ventilation or impending mortality.
*Relative risk is for IMV.
Further information on bdbiosciences.com/Covid-19-TBNK-IFU
Use the BD Multitest™ 6-Color TBNK Reagent with BD Trucount™ Tubes to augment COVID-19 patient workup.
This test generates the percentages and absolute counts of T, B and natural killer (NK) cells as well as the CD4 and CD8 subpopulations of T-cells in peripheral blood.
This is a trusted test now with predetermined cut-off values for specific lymphocyte T-cells subsets (CD4+ and/ or CD8+) to identify COVID-19 patients at increased risk for IMV, and increased risk of mortality at hospital admission, in conjunction with clinical findings and the results of other laboratory testing.
Complete Blood Count
A complete blood count (CBC) test captures lymphopenia in the blood but is unable to measure the specific lymphocyte populations that are impacting normal immune response.
Immune Response in COVID-19 patients
Individuals with COVID-19 typically exhibit a decrease of CD4+ and/or CD8+ counts with increasing disease severity.1
The right course of action.
For the right patient.
At the right time.
All with the right tests.
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