Sample collection and accurate analysis comes with many clinical, technical and operational challenges

Biomarker stabilisation is key

Standardised processes are important to ensure biomarker specimen stability and preserve the integrity of biomarker specimens. It is no secret that sample collection and accurate analysis comes with many clinical, technical and operational challenges, including:

  • Sample stability
  • Sample storage and transport
  • Data reproducibility
  • Processing time
  • Supply reliability
  • Biohazard exposure risks

At BD, our range of cell and biomarker stabilisation tubes are intended to maintain sample quality from collection, through transport and storage, all the way to final analysis to optimise your workflow.1

Downstream applications

Exploring biomarkers from discovery to clinical diagnosis

The BD Vacutainer® family of products offers cell and biomarker preservation to support generation of accurate and reproducible data across a number of molecular, proteomic, and cellular applications. Discover how cell and biomarker preservation tubes can optimise the preanalytical workflow in your field of research.

Proteomics

Your choice of blood tube impacts the accuracy of measuring GLP-1 and glucagon.2

RNA stabilisation

The ability to stabilise, analyse and manipulate ex vivo gene expression as if it is still in the body is essential to the development of new gene therapies.

RNA research

Protection of RNA from enzymatic degradation can provide a snapshot of the gene expression profile at the time of blood collection, leading to advancements in genomics research.



Oncology research

RNA quickly loses its structural integrity once removed from the cell. Capturing a snapshot of RNA from cancer cells relies on sample stabilisation at the point of collection.

Circulating cell-free DNA

Circulating cell-free DNA (ccfDNA) is a key biomarker for non-invasive prenatal testing (NIPT) and liquid biopsy and can provide a breadth of information to researchers and clinicians.

Immunology

Blood mononuclear cells, such as lymphocytes, monocytes and dendritic cells are key to understanding elements of an effective immune response.


Minimise preanalytical variability and ensure success in your obesity and diabetes clinical trials. Stabilise peptides critical to your diabetes and obesity clinical trials for >96h.2


Download the P800 brochure

Our solutions

BD - The trusted name in biomarker stabilization

For over 70 years, BD has been a trusted name for blood specimen management solutions. The BD Vacutainer® family of products for blood cell and biomarker preservation are widely used in clinical and biomarker research across the world, in conjunction with a variety of downstream molecular, proteomics and cellular applications. These products can help ensure consistency in results, accuracy of data and workflow efficiency when measuring biomarkers.

BD P800 Blood Collection Tubes BD Vacutainer® CPT™ Tubes PAXgene® Blood RNA Tubes PAXgene® Blood ccfDNA Tubes

BD P800 Blood Collection Tubes

The BD P800 Blood Collection Tube contains a blend of proprietary protease inhibitors optimised to stabilise GLP-1, glucagon, oxyntomodulin (OXM) and GIP, enhancing metabolic peptide quantification accuracy.2

BD P800 efficiently inhibits the proteolysis of metabolic biomarkers crucial to diabetes and obesity clinical trials.2


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Cell Preparation Tubes (CPT™)


Resources

Watch a webinar, read a relevant study or check out our product brochures. -Watch a webinar-Research studies-Product brochures-Technical notes-CE marking for In Vitro Diagnostic use for the PAXgene® Blood ccfDNA Tube.


Watch a webinar


Blood RNA workflow in molecular in vitro diagnostic testing

Dr Kalle Gunther and Dr Faraia Shah from PreAnalytiX discuss ways to enhance the preanalytical blood RNA workflow for molecular diagnostic testing.

Watch the webinar

Optimise your liquid biopsy workflow


Do you want to optimise your liquid biopsy sample quality? Join our webinar discussing how to achieve the best result for your assay.

Watch the webinar


Research studies
Sensitivity of liquid biopsy assay

Circulating cell-free DNA (ccfDNA) is used in a number of diagnostic assays which require specified preanalytical workflows to facilitate correct and reliable results. This research article by Thorsten Voss, Andrea Ullius, Maike Schönborn, and Uwe Oelmüller establishes a blueprint for a test procedure to verify and validate a liquid biopsy workflow.

Discover the study


Product brochures


BD P800 Blood Collection Tube

Your choice of blood tube impacts the accuracy of measuring GLP-1, GIP and glucagon.2 The BD P800 Blood Collection Tube contains a blend of proprietary protease inhibitors optimised to stabilise GLP-1, glucagon, oxyntomodulin (OXM) and GIP, enhancing metabolic peptide quantification accuracy.

Discover the brochure

PAXgene® Blood RNA Tube

The PAXgene® Blood RNA System is the first IVD-marketed product for the collection, storage and transportation of whole blood with stabilisation of intracellular RNA in a closed tube and subsequent isolation and purification of intracellular RNA for RT-PCR used in molecular diagnostic testing.

Discover the brochure


Technical notes
PAXgene® Blood ccfDNA transport, robustness and plasma & plasma stability

Check out these three technical notes on our PAXgene® Blood ccfDNA Tube (CE-IVD) solution covering sample transport, plasma and nucleated cellular fraction stability and tube robustness.


Read the technical notes


Circulating cell-free DNA and plasma


ccfDNA in Vitro Diagnostic

CE marking for In Vitro Diagnostic use for PAXgene® Blood ccfDNA Tube

Do you need support for your IVDR implementation?

The PAXgene® Blood ccfDNA Tube (CE-IVD) is now CE marked for In Vitro Diagnostic use according to the Regulation EU 2017/746 on In Vitro Diagnostic Medical Devices (IVDR). Read our customer letter to learn more.

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BD Vacutainer CPT™ tubes

BD Vacutainer CPT™ tubes Mononuclear Cell Preparation Tubes provide simple, one-step isolation of peripheral blood mononuclear cells (PBMCs) from whole blood in a primary blood collection tube.
The fully closed, one-tube processing provides a unified collection and separation step (in comparison to FICOLL™ gradient methods), helping to streamline your sample processing from preparation to post-centrifugation.

  • Removes possible variations in plasma preparations
  • Reduces blood exposure for laboratory staff
  • Reduces waiting times during centrifugation with brakes enabled

Following centrifugation, the patented gel barrier provides clear cell separation with no aliquoting or additional consumables. Cells are stable in the BD CPT™ Tube allowing centrifuged samples to be safely transported.


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BD Vacutainer CPT™ tubes

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PAXgene® Blood RNA Tubes

RNA is inherently less stable than DNA. RNA transcript levels can change within minutes of blood collection resulting in gene expression levels that are not representative of the real RNA transcript profile.
PAXgene® Blood RNA Tubes give you the ability to capture more accurate RNA profiles by stabilising RNA at the time of collection. This single tube integrates collection, stabilisation transport, and storage to enhance your preanalytical blood RNA workflow and minimise unpredictability associated with RNA processing. Specimens can then be stored at room temperature (18 to 25°C) for up to 3 days


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*Studies ongoing

PAXgene® Blood RNA Tubes

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PAXgene® Blood ccfDNA tubes
(CE-IVD)

PAXgene® Blood ccfDNA Tube (CE-IVD) is now CE marked for In Vitro Diagnostic use according to the Regulation (EU) 2017/746 on In Vitro Diagnostic Medical Devices (IVDR)

For collection of whole blood samples and stabilization of circulating cell-free (ccfDNA) from plasma and gDNA from the nucleated cellular fraction
Single tube collection, stabilization, transport and storage
Formaldehyde-free, non-crosslinking stabilization of circulating, cell-free DNA (ccfDNA)
Stabilization of ccfDNA in plasma and genomic DNA (gDNA) in the nuclear cellular fraction for days at various temperatures facilitates transport and storage
Standardized preanalytical processing of samples
Length of stabilization of whole blood
2-37°C for up to 3 days
2-30°C for up to 7 days
2-25°C for up to 10 days
Do not store blood-filled tubes below 2°C


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PAXgene® Blood ccfDNA tubes (CE-IVD)

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Advancing healthcare

As a healthcare professional, you face daily challenges in pursuing quality, ensuring consistent supply and striving to improve patient outcomes. How can we collaborate to address these challenges and advance healthcare with innovation and sustainability?

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